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. 2019 Feb 21;15(2):e1007977. doi: 10.1371/journal.pgen.1007977

Fig 3. VGLL4 ablation in endothelial cells leads to arterial valves thickening.

Fig 3

(A,C) Sirius Red staining of postnatal (P0) arterial heart valves from Wnt1Cre+;Vgll4fl/-; Tie2Cre+;Vgll4fl/- and Vgll4fl/- controls. (B,D) Quantitation of aortic valve area (B) and pulmonary valve area (D) from postnatal Wnt1Cre+;Vgll4fl/- (n = 4), Tie2Cre+;Vgll4fl/- (n = 7) and Vgll4fl/- controls (n = 11). (E,G) Sirius Red staining of adult (36 weeks) arterial valves from Wnt1Cre+-;Vgll4fl/-; Tie2Cre+;Vgll4fl/- and Vgll4fl/- controls. (F,H) Quantitation of aortic valve area (F) and pulmonary valve area (H) from adult Wnt1Cre+;Vgll4fl/- (n = 5), Tie2Cre+;Vgll4fl/- (n = 5) and Vgll4fl/- controls (n = 8). Scale bar = 200μm. *P<0.05, **P<0.01, ns: no significance.