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. 2019 Mar 5;2019(3):CD011571. doi: 10.1002/14651858.CD011571.pub2

Summary of findings 2. Erythromycin compared to no treatment for guttate psoriasis.

Erythromycin compared to no treatment for guttate psoriasis
Patient or population: guttate psoriasis
Setting: inpatients in department of dermatology
 Intervention: erythromycin
 Comparison: no treatment
Outcomes Anticipated absolute effects* (95% CI) Relative effect
 (95% CI) № of participants
 (studies) Certainty of the evidence
 (GRADE) Comments
Risk with no treatment Risk with erythromycin
Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 Not measured
Proportion of participants with adverse events and severe adverse events Not measured
Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) Not measured
Proportion of participants achieving PASI 75 or PGA 1 to 2 Not measured
Results were only reported as mean PASI at baseline and at 6 weeks. No difference was found between groups for mean PASI at 6 weeks.
Risk of having at least one relapse at long‐term follow‐up Not measured
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 
 CI: Confidence interval; RR: Risk ratio; OR: Odds ratio;
GRADE Working Group grades of evidenceHigh quality/certainty: We are very confident that the true effect lies close to that of the estimate of the effect
 Moderate quality/certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
 Low quality/certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
 Very low quality/certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect