Table 3.

List of OP-associated CpGs from blood based DNA methylation and their association in saliva based DNA methylation replication samples.

CpG	Chr	Position (bp)	Probe SNPs	Probe SNPs 10	Gene	Gene region	PEG1 - blood DNA (n = 579)		PEG2 - saliva DNA (n = 231)
							cor	p value	cor	p value
cg19952704	4	187,751,549					−0.23	1.67E−08	−0.24	2.10E−04
cg05995465	2	240,313,602		rs6147245	HDAC4	5′UTR	0.21	4.28E−07	0.22	7.02E−04
cg06193597	2	241,896,910		rs10173220			−0.21	4.22E−07	−0.22	8.75E−04
cg08354527	1	229,252,042		rs2125454			−0.21	3.12E−07	−0.22	9.42E−04
cg21598190	7	2,099,404		rs6953670	MAD1L1	Body	0.22	1.09E−07	0.21	1.44E−03
cg12856521	11	46,389,249		rs34470543	DGKZ	Body	−0.23	4.41E−08	−0.21	1.57E−03
cg22996768	19	33,719,749					−0.23	2.17E−08	0.20	1.79E−03
cg02059823	2	240,872,433		rs73101773			0.23	3.70E−08	0.19	3.98E−03
cg15680603	6	33,037,413	rs1126542	rs35171346	HLA-DPA1	Body	0.20	7.94E−07	0.16	1.42E−02
cg11927033	6	122,793,073		rs3752576	PKIB; SERINC1	1st exon; 5′UTR; TSS200	0.25	1.14E−09	0.16	1.49E−02
cg15145296	3	125,709,740					0.21	3.49E−07	0.16	1.84E−02
cg14044167	8	134,271,505			NDRG1	Body	0.22	9.91E−08	−0.15	1.86E−02
cg17858192	4	16,077,807			PROM1	TSS200; TSS200; 5′UTR	−0.23	2.51E−08	0.14	3.04E−02
cg15138543	4	987,391		rs3806756	IDUA; SLC26A1	Body; TSS1500; TSS200	−0.20	8.12E−07	−0.13	5.15E−02

Chr Chromosome, bp base pair, TSS transcription start site, TSS1500 within 1500 bps of a TSS, TSS200 within 200 bps of a TSS, UTR untranslated region, SNPs listing dbSNP entries within a probe, SNPs_10 listing dbSNP entries within 10 bp of the CpG site.

These are CpGs with p values < 0.05 from saliva DNA methylation replication analyses; adjusting for PD, age, sex, and European ancestry.

Blood-based DNA population (PEG1) and saliva-based DNA population (PEG2) are comprised of different participants.