Figure.

Subdomain organization of Kindlin-2. (Top) Subdomains of Kindlin-2 and their corresponding sequence numbers. (Bottom) Crystal structure of Kindlin-2 (PDB code 5xpy) with subdomains highlighted. Note that F2-N is the N-terminal portion of F2 prior to PH domain since the structure lacks PH domain and C-terminal F2 part. Certain regions that are under investigation are highlighted by arrows including C-terminal helix that bridges F1 and F3; QW that interacts with integrin; and clathrin box that potentially binds to clathrin.