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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: J Bone Miner Res. 2018 Jun 22;33(10):1760–1772. doi: 10.1002/jbmr.3473

Figure 6.

Figure 6.

Male oim/oim mice exhibited upregulation of osteoblast, osteoclast, and osteocyte marker genes as compared to WT counterparts. A) Relative fold changes of vehicle treated +/G610C and oim/oim Runx2, Sp7 (Osterix), Dlx5, Alpl (Alkaline phosphatase), Serpinh1 (Hsp47), and Bglap (osteocalcin), B) Csf1 (M-CSF), Tnfsf11 (RANKL), Itgb3 (Integrinβ−3), and Ctsk (Cathepsin K), and C) Dmp1, Phex, Sost (sclerostin), and β-cat (β catenin) mRNA levels with respect to vehicle treated WT mice. (n=10 WT+vehicle [blue], n=8 +/G610C+vehicle [red], and n=11 oim/oim+vehicle [green]) (Alpl gene expression levels of WT and oim/oim sample size were 7 and 8, respectively). Values are MEAN±SD. *p<0.05; †p<0.05 vs. WT+vehicle treated mice; *ap=0.0676.