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. 2019 Mar 4;151(3):357–368. doi: 10.1085/jgp.201812276

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© 2019 Ndaru et al.

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Figure 5. — Inhibitor affinity correlates with the hydrophobicity of the hydrocarbon side chain. Log(K_i) is plotted as a function of log(P) of the side chain. Log(P) was calculated according to (Petrauskas and Kolovanov, 2000). R² for the linear regression (solid line) is 0.74. Pearson’s r value is −0.88, indicating good correlation. Compound 2b was excluded from the fit (red square) because of borderline substrate-like properties.