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. 2019 Mar 4;151(3):357–368. doi: 10.1085/jgp.201812276

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© 2019 Ndaru et al.

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Figure 6. — The inhibition mechanism is competitive. (A–E) Determination of inhibition constant K_i for compound 16b at different concentrations of alanine. The red lines are fits of the currents according to the following equation: I = I₁ + I₂ [Inh]/(K_i + [Inh]), where I₁ is the alanine-induced current without inhibitor, and I₂ is the maximum current in the presence of saturating inhibitor concentration, [Inh]_max (Albers et al., 2012). (F) K_I plotted as a function of the alanine concentration, showing a linear relationship according to the equation K_i(Ala) = K_i(0) + [Ala] K_i(0)/K_m(Alanine), where K_i(Ala) and K_i(0) are the K_I values in the presence and absence of alanine and K_m(Alanine) is the apparent Michaelis–Menten constant for alanine activation of anion current. Error bars represent ±SD.