Figure 10.

Voltage sensor equilibrium gating scheme. (A) Gating scheme in which τ_act is determined by the probability that voltages sensors are in their activated state. Activation of four identical resting voltage sensors is determined by the α/β equilibrium. Pore opening is a voltage-independent concerted event with rate k_open and reverse rate k_close. Equilibrium susceptible to GxTx is red. (B) Fit of Eq. 9 to τ_act from Fig. 2 C. Dashed line, (k_open + k_close)⁻¹ = 5.1 ± 0.1 ms; black solid line, vehicle; ${\beta }_{0mV}/{\alpha }_{0mV}$ = 0.33 ± 0.01, z = 0.61 ± 0.06 e₀; red solid line, 1 µM GxTx, ${\beta }_{0mV}/{\alpha }_{0mV}$ = 1.2 ± 0.2, z = 0.45 ± 0.04 e₀. Hollow black circles or diamonds, τ_act values.