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. 2019 Mar 4;151(3):342–356. doi: 10.1085/jgp.201812263

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© 2019 Kapoor et al.

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Figure 7. — Summary of effects of ADs on gA channel activity in the single-channel assay. (A and B) Normalized (A) AgA(15) and (B) gA⁻(13) lifetimes, τ_AD,15/τ_cntrl,15 and τ_AD,13/τ_cntrl,13, respectively, with increasing concentration of the given AD. The colors represent different ADs: amitriptyline (purple), imipramine (pink), fluoxetine (S+; red), fluoxetine (R−; orange), citalopram (S+; blue), citalopram (R−; green).. (C) The ratio of normalized gA⁻(13) versus the normalized AgA(15) single-channel lifetimes at different drug concentrations. A ratio >1 (denoted by the dashed line) indicates a greater effect on channels formed by the shorter gA analogue by the given drug at that concentration. Values represent mean ± SE; n = 3–4.