Table 2. AD surface densities and mole fractions in the bilayer and the actual aqueous concentrations required to double the fluorescence quench rate.

				Estimated usingK1			Estimated using cLogP
AD	DAD	LogK1	cLogP	{AD}L	mAD	[AD]W	{AD}L	mAD	[AD]W
	μM			moles/cm2		μM	moles/cm2		μM
Fluoxetine	17	3.61	4.27	5.5⋅10−12	0.023	8.7	9.0⋅10−12	0.037	3.5
Paroxetine	30	3.35	3.68	6.7⋅10−12	0.028	20	9.7⋅10−12	0.040	15
Sertraline	31	4.51	5.18	17⋅10−12	0.068	5.4	20⋅10−12	0.078	1.6
Amitriptyline	53	3.59	4.72	14⋅10−12	0.056	32	29⋅10−12	0.11	9.0
Imipramine	82	3.31	3.71	14⋅10−12	0.057	61	21⋅10−12	0.084	50
Fluvoxamine	84	2.61	3.04	5.0⋅10−12	0.021	76	9.9⋅10−12	0.041	69
Alaproclate	220	2.43	2.58	8.0⋅10−12	0.033	210	10⋅10−12	0.042	200
Citalopram	250	2.64	3.39	12⋅10−12	0.050	230	30⋅10−12	0.12	200
Zimelidine	290	2.40	3.69	9.3⋅10−12	0.039	280	24⋅10−12	0.092	250
Clomipramine	39		5.29				25⋅10−12	0.096	1.7
Lofepramine	42		6.26				28⋅10−12	0.11	0.2
Protriptyline	52		4.70				29⋅10−12	0.11	9.0
Nortriptyline	61		4.76				33⋅10−12	0.13	11
Trimipramine	72		4.98				41⋅10−12	0.15	10
Dothiepin	83		4.65				41⋅10−12	0.15	22
Desipramine	97		4.28				37⋅10−12	0.14	41
Doxepin	160		4.27				50⋅10−12	0.18	85

{AD}_L, m_AD and [AD]_W were calculated from Eqs. S29–S31 using either the experimental ($K_2=K_1\cdot d_0/2$) or estimated ($K_2^{\text{'}}={10}^{\mathrm{cLogP}}\cdot d_0/2$) adsorption coefficients, where cLogP is the consensus value from the ACD/Percepta PhysChem Suite. $V_{\mathrm{W}}$ = 1.5 ml, ${\langle \mathrm{Lipid}\rangle }_{\mathrm{T}}$ = 37.3 μmol, $a_{\mathrm{L}}$= 0.7 nm², d₀ (the DC_22:1PC bilayer phosphate to phosphate thickness, 4.5 nm; Lewis and Engelman, 1983), and $a_{\mathrm{D}}$ = 0.3 nm².