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. 2019 Mar 4;216(3):539–555. doi: 10.1084/jem.20182184

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© 2019 Croft et al.

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Figure 7. — Increased cell death follows mature neurofibrillary inclusion formations in tau-transduced BSCs. (A) Representative images of EthD-1 uptake (red fluorescence) in BSCs transduced with rAAV2/8-EGFP, rAAV2/8-WT-htau, or rAAV2/8-A152T/P301L/S320F-htau (1–2 × 10¹⁰ VGs per well) and imaged at 7, 28, and 60 DIV. Bar, 400 µm. (B) Bar chart shows numbers of EthD-1–positive (red) cells per mm² in rAAV2/8-EGFP, rAAV2/8-WT-htau, rAAV2/8-S320F-htau, rAAV2/8-P301L/S320F-htau, rAAV2/8-A152T/P301L/S320F-htau, or no rAAV-transduced BSCs at 7, 14, 21, 28, and 60 DIV. Data are mean ± SEM. *, P < 0.05. n = 6–12.