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. 2019 Mar 4;216(3):482–500. doi: 10.1084/jem.20182031

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© 2019 Tretina et al.

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Figure 5. — Antimicrobial activities of GBPs. (A) Targeting of human GBP1 to cytosolic S. typhimurium via live epifluorescent imaging in IFN-γ–activated human HeLa epithelium. Bar, 3 µm. Courtesy of A. Maminska. (B) Specific cell-autonomous responses of GBPs to different pathogen classes and the downstream consequences of their antimicrobial actions in humans (h), mice (m), and zebrafish (z). (C) Involvement of different GBPs from humans, mice, and zebrafish in canonical and noncanonical inflammasome activation elicited by microbial ligands as input signals. Cytokine and prostaglandin secretion plus pyroptosis are identified outputs. Inflammasome cryoelectron tomography structure (3JBL) from https://www.ebi.ac.uk/pdbe. MDP, muramyl dipeptide.