Table 1. Immune phenotypes in GBP KO mice and disease-associated SNPs/gene alterations in humans.

GBP deficiency	Disease or immune challenge	Phenotype	Reference
GBP KO mice
Gbp1−/−	L. monocytogenes	Susceptible to orogastric infection	Kim et al. (2011)
	M. bovis BCG	Susceptible to i.v. infection	Kim et al. (2011)
	T. gondii	Susceptible to s.c. infection	Selleck et al. (2013)
Gbp2−/−	T. gondii	Susceptible to i.p. infection	Degrandi et al. (2013)
	L. monocytogenes	Resistant to i.p. infection	Degrandi et al. (2013)
	F. novicida	Susceptible to s.c. infection and reduced serum IL-18	Meunier et al. (2015)
	OMV i.p. challenge	Resistant to endotoxemia after poly I:C priming; reduced serum IL-1β plus IL-18	Finethy et al. (2017); Santos et al. (2018)
Gbp5−/−	L. monocytogenes	Susceptible to orogastric infection and insensitive to the caspase-1 inhibitor z-YVAD-FMK	Shenoy et al. (2012)
	LPS i.p. challenge	Reduced serum IL-1β plus IL-18 and reduced active caspase-1 in splenic macrophages	Shenoy et al. (2012)
	MDP i.p. challenge	Impaired peritonitis and reduced active caspase-1 in peritoneal neutrophils	Shenoy et al. (2012)
	Alum i.p. challenge	Normal peritonitis	Shenoy et al. (2012)
	MSU i.p. challenge	Normal peritonitis	Shenoy et al. (2012)
Gbpchr3−/−	T. gondii	Susceptible to i.p. infection	Yamamoto et al. (2012)
	L. monocytogenes	Resistant to i.p. infection	Yamamoto et al. (2012)
	F. novicida	Susceptible to s.c. infection and reduced serum IL-18	Meunier et al. (2015); Man et al. (2016); Wallet et al. (2017)
	L. pneumophila	Susceptible to cytosolic ΔsdhA Lpn administered oropharangeally	Liu et al. (2018)
	Norovirus	Susceptible to peroral infection in combination with Ifnar1 deficiency	Biering et al. (2017)
	OMV i.p. challenge	Resistant to endotoxemia after poly I:C priming; reduced serum IL-1β plus IL-18	Finethy et al. (2017); Santos et al. (2018)
	LPS i.p. challenge	Resistant to endotoxemia after poly I:C priming; reduced serum IL-1β plus IL-18	Santos et al. (2018)
Human GBP SNPs/alterations
GBP2	Hepatitis B virus	IFN treatment responsiveness vs. nonresponsiveness	King et al. (2002)
(41544 A/G)a
(41556 G/C)a
GBP3 (rs7911)	Fibromyalgia	Protective role in pathophysiology of FM	Parisien et al. (2017)
GBP5 (spliced GBP5ta-97 AA truncation)	Cutaneous T cell lymphoma	High isoform expression in tumor tissues and cell lines	Fellenberg et al. (2004)
GBP7 (rs1803632)	Malaria	Promoter mutations associated with higher disease incidence	Apinjoh et al. (2014)

rs, dbSNP database number; MDP, muramyl dipeptide; MSU, monosodium ureate; FM, fibromyalgia.

^aJSNP, Japanese Single Nucleotide Polymorphisms database.