. 2019 Mar 4;216(3):656–673. doi: 10.1084/jem.20180749

Table 1. Univariate and multivariate Cox proportional hazards analysis of clinicopathological factors for OS and RFS.

Variables	OS		RFS
Variables	HR (95.0% CI)	P	HR (95.0% CI)	P
Univariate analysis
Age	0.932 (0.570–1.524)	0.780	0.805 (0.508–1.275)	0.355
Sex	1.398 (0.855–2.287)	0.182	1.335 (0.842–2.114)	0.219
Histological grade	1.772 (1.058–2.969)	0.030^a	1.621 (1.001–2.627)	0.05
Tumor size	1.133 (0.688–1.868)	0.624	1.058 (0.664–1.684)	0.813
pTNM stage	2.174 (1.153–4.100)	0.016^a	2.462 (1.363–4.447)	0.003^a
LN metastasis	1.417 (0.768–2.612)	0.265	1.440 (0.816–2.543)	0.209
EHF expression	0.257 (0.134–0.492)	0.000^a	0.293 (0.162–0.532)	0.000^a
CD8	0.561 (0.324–0.972)	0.039^a	0.676 (0.411–1.114)	0.124
T reg cell	1.742 (1.061–2.862)	0.028^a	1.520 (0.956–2.417)	0.077
MDSC	1.906 (1.088–3.339)	0.024^a	1.897 (1.126–3.195)	0.016^a
Multivariate analysis
pTNM stage	1.977 (1.041–3.754)	0.037^a	2.344 (1.292–4.255)	0.005^a
EHF expression	0.267 (0.139–0.514)	0.000^a	0.338 (0.184–0.623)	0.001^a

Data were based on tissue IF assay. Multivariate Cox proportional hazards analysis used backward selection model. HR, hazard ratio; CI, confidence interval.

Statistically significant (P < 0.05).