Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 4;216(3):517–526. doi: 10.1084/jem.20181169

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Dimitrov et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 2. — Effect of Gα_s-coupled receptor agonists on pMHC-induced β₂-integrin activation on antigen-specific CD8⁺ T cells. (A–F) Whole blood cells and (for adenosine) PBMCs were preincubated in the presence or absence of the indicated Gα_s-coupled receptor agonists at the indicated concentrations for 5 min followed by staining with CMV A2-NLV/PE (A, C, E, and F) or EBV A2-GLC/PE (B and D) multimers and mICAM-1 for 5 min at 37°C. Means ± SEM of the MFI of mICAM-1 binding are shown for the different agonists as percentage of the control (i.e., the sample without Gα_s-coupled receptor agonists, which was set to 100%). The fitted standard curves were calculated by nonlinear regression; n = 5 (n = 3 for adenosine, serotonin, histamine, and dopamine).