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. 2019 Mar 4;216(3):517–526. doi: 10.1084/jem.20181169

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© 2019 Dimitrov et al.

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Figure 3. — Sleep increases β₂-integrin activation on antigen-specific CD8⁺ T cells. (A–E) Means ± SEM of the MFI of mICAM-1 binding on total CMV-specific (A) and EBV-specific (B) CD8⁺ T cells, as well as on early (CD27⁺CD28⁺; C), intermediate (CD27⁺CD28⁻; D) and late (CD27⁻CD28⁻; E) differentiated CMV-specific CD8⁺ T cell subpopulations after staining with pMHC multimers and mICAM-1 are shown for a regular sleep–wake cycle (sleep, filled circles) and continuous wakefulness (wake, open circles). Gray lines illustrate adapted cosine curves for confirmed circadian rhythms in the sleep condition; the shaded area depicts bedtime. Significance is indicated for pairwise comparisons between conditions using paired t tests following significant ANOVA results. n = 10 for CMV; n = 5 for EBV; *, P < 0.05.