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. 2019 Mar 4;216(3):517–526. doi: 10.1084/jem.20181169

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© 2019 Dimitrov et al.

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Figure 4. — Regulation of integrin activation by plasma collected during sleep versus wakefulness is mediated by Gα_s-coupled receptor signaling. (A and B) Means ± SEM of the MFI of mICAM-1 binding are shown on CMV-specific CD8⁺ T cells incubated with plasma collected at 2 am during sleep versus wakefulness (A) and at 6 am (during nocturnal sleep) versus 6 pm (during daytime wakefulness; B). CMV-specific T cells were incubated with plasma collected at the indicated time points and conditions (sleep vs. wake) in the presence or absence of an antagonist composite (including β₂-AR, EP₄, and DP₁ antagonists) or in the presence or absence of an agonist composite (including epinephrine, norepinephrine, PGE₂, and PGD₂). All experiments were performed in duplicates. Significance is indicated for pairwise comparisons between conditions or treatments using paired t tests. n = 6; **, P ≤ 0.01; ***, P < 0.001.