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. 2019 Mar 4;218(3):1027–1038. doi: 10.1083/jcb.201806148

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© 2019 Heymann et al.

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Figure 3. — Reconstruction of the type I alternating configuration unit cell at ∼10-Å resolution (EMDB accession no. 7907) with two docked 16-mer molecules (PDB accession no. 3JD6). (A) Side view of the two 16-mer molecules in the unit cell, with the outside rings (top right and bottom left) somewhat more curved than the inside rings (top left and bottom right). (B) Close-up view of the interaction between neighboring molecules, showing the Y93 side chains as stick models (arrows). Y93 is part of an apparently flexible loop, P₅₆EQYVGWY₉₃SSWTA₉₈, that fits into the connecting density between the molecules and is thus thought to form the main interaction. In this loop, mutations in Y89, G91, W92, and Y93 are associated with XLRS.