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Inducer scope and function of the MphR biosensor. (A) Examples of naturally produced macrolides that are MphR inducers. (B) Scheme illustrating the artificial MphR regulatory system. In the presence of a macrolide activator, MphR undergoes a conformational change and leaves the cognate operator sequence, allowing transcription of the downstream reporter, GFP. For clarity, phosphorylation of ErA via MphA (MphA housed in pJZ12) is omitted from the figure.
