Figure 3. AKT and Wnt/β-catenin signaling pathways are down-regulated by ABT263 and AXIT combination in KRAS-mutant colon cancer cells.
(A) Western blots of p-AKT and p-ERK for HCT116 cells treated by single or combination drugs. (B) Western blots of p-AKT and p-ERK for HCT15 cells treated by single or combination drugs. (C) Western blots of p-β-catenin, p-AKT, and p-GSK3β for HCT116 cells treated by single or combination drugs. (D) Western blots of p-β-catenin, p-AKT, and p-GSK3β for HCT15 cells treated by single or combination drugs.