Table 3.
Univariate and multivariate regression analysis of the influence of factors on the survival of patients with MDS.
| Variable | 5-year survival | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Log rank χ2 test | P | HR (95%CI) | P | ||
| Gender | 153.143 | <0.001 | |||
| Male | 27.6% | 1.243(1.209-1.278) | <0.001 | ||
| Female | 33.6% | Reference | |||
| Age | 2779.272 | <0.001 | |||
| <60 y | 52.7% | Reference | |||
| 60-69 y | 40.2% | 1.540(1.459-1.624) | <0.001 | ||
| 70-79 y | 30.7% | 2.034(1.937-2.137) | <0.001 | ||
| ≥80 y | 16.9% | 3.014(2.868-3.167) | <0.001 | ||
| Race | 101.353 | <0.001 | |||
| White | 29.4% | Reference | |||
| Black | 38.7% | 0.912(0.868-0.958) | <0.001 | ||
| Other§ | 31.6% | 0.993(0.944-1.046) | 0.801 | ||
| Year of diagnosis | 5.233 | 0.022 | |||
| 2001-2007 | 30.8% | Reference | |||
| 2008-2014 | 29.7% | 1.018(0.990-1.046) | 0.212 | ||
| Marital Status | 568.582 | <0.001 | |||
| Married | 33.0% | Reference | |||
| Never married | 36.9% | 0.910(0.870-0.950) | <0.001 | ||
| Divorced/Separated | 31.6% | 1.060(1.011-1.111) | 0.015 | ||
| Widowed | 21.4% | 1.381(1.341-1.423) | <0.001 | ||
| Histologic Type | 2113.316 | <0.001 | |||
| RA | 40.7% | Reference | |||
| RN | - | - | |||
| RT | - | - | |||
| RAS | 46.4% | 0.851(0.799-0.906) | <0.001 | ||
| RCMD | 28.0% | 1.365(1.275-1.461) | <0.001 | ||
| RAEB | 11.2% | 2.686(2.549-2.831) | <0.001 | ||
| RAEB-t | 8.5% | 3.240(2.739-3.834) | <0.001 | ||
| MDS 5q- | 28.5% | 1.326(1.210-1.453) | <0.001 | ||
| MDS/MPN | 46.2% | 1.014(0.924-1.112) | 0.770 | ||
| t-MDS | 26.6% | 1.703(1.406-2.062) | <0.001 | ||
| MDS-NOS | 30.2% | 1.302(1.245-1.361) | <0.001 | ||
§Other includes American Indians/Alaska natives, Asian/Pacific Islanders. Unable to statistics the 5-year survival of RN and RT because no data in the SEER.