Table 4.
Univariate and Multivariate analysis of risk factors for lymph node metastasis in 81 patients with early mixed signet-ring cell gastric carcinoma
| Univariate analysis of risk factors for LNM in 81patients with early gastric mSRCC | |||||
| Clinicopathologic Feature | Total Number | Lymph Node Metastasis | Percent (%) | P Value | |
| Absence | Presence | ||||
| Age (year) | |||||
| ≤65 | 64 | 45 | 19 | 29.7 | NS |
| >65 | 17 | 14 | 3 | 17.6 | |
| Gender | |||||
| Male | 60 | 45 | 15 | 25.0 | NS |
| Female | 21 | 14 | 7 | 33.3 | |
| Location | |||||
| cardia | 7 | 6 | 1 | 14.3 | NS |
| body | 28 | 22 | 6 | 21.4 | |
| angularis | 9 | 8 | 1 | 11.1 | |
| antrum | 32 | 20 | 12 | 37.5 | |
| pylorus | 5 | 3 | 2 | 40.0 | |
| Gross pattern | |||||
| 0-I | 1 | 1 | 0 | 0.0 | NS |
| 0-2a | 10 | 7 | 3 | 30.0 | |
| 0-2b | 12 | 9 | 3 | 25.0 | |
| 0-2c | 16 | 11 | 5 | 31.3 | |
| 0-3 | 42 | 31 | 11 | 26.2 | |
| Tumor size(cm) | |||||
| ≤ 2.0 | 39 | 33 | 6 | 15.4 | < 0.05 |
| > 2.0 | 42 | 26 | 16 | 38.1 | |
| Invasion depth | |||||
| M | 42 | 34 | 8 | 19.0 | NS |
| SM | 39 | 25 | 14 | 35.9 | |
| Lymphovascular invasion | |||||
| Absence | 67 | 56 | 11 | 16.4 | <0.0001 |
| Presence | 14 | 3 | 11 | 78.6 | |
| Hp infection | |||||
| Absence | 35 | 24 | 11 | 31.4 | NS |
| Presence | 46 | 35 | 11 | 23.9 | |
| Atrophic gastritis | |||||
| Absence | 34 | 28 | 6 | 17.6 | NS |
| Presence | 47 | 31 | 16 | 34.0 | |
| Ulcer finding | |||||
| Absence | 33 | 20 | 13 | 39.4 | NS |
| Presence | 48 | 39 | 9 | 18.8 | |
| Mixed pathological type | |||||
| p/D | 62 | 45 | 17 | 27.4 | NS |
| m/D | 19 | 14 | 5 | 26.3 | |
| Multivariate analysis of risk factors for LNM in 81patients with early gastric mSRCC | |||||
| P value | Odds ratio | 95% Confidence intervals | |||
| Tumor size | < 0.05 | 2.1 | 1.0 - 4.1 | ||
| Lymphovascular invasion | <0.0001 | 22.2 | 4.8 - 103.1 | ||
NS: not significant; p/D:poorly differentiated adenocarcinoma; m/D:middle differentiated adenocarcinoma; mSRCC: mixed signet-ring cell carcinoma; Hp: helicobacter pylori; LNM: lymph node metastasis; M: intramucosal; SM: submucosal invasion.