Table 1. Comparison of clinical characteristics and JL1 expression status in 78 de novo pediatric acute leukemia patients at diagnosis with respect to disease subgroups.
| Variables | ALL∥ (N = 52) | AML (N = 26) | P |
|---|---|---|---|
| Sex (M : F) | 27 : 25 | 15:11 | 0.630§ |
| Age (month)* | 67.0 (2.0–216.0) | 156.0 (18.0–216.0) | < 0.001‡ |
| WBC (× 109/L) | 51.86 ± 113.09 | 94.20 ± 149.10 | 0.166† |
| Hb (× 10 g/L) | 8.14 ± 2.46 | 7.17 ± 1.60 | 0.072† |
| PLT (× 109/L) | 69,650 ± 57,410 | 93,810 ± 104,310 | 0.190† |
| Blast in PB (%) | 54.27 ± 33.02 | 50.77 ± 35.10 | 0.667† |
| Blast in BM (%) | 83.15 ± 17.15 | 73.68 ± 23.46 | 0.046† |
| Days from Dx to 1st CR* | 33.0 (13.0–182.0) | 50.0 (27.0–285.0) | 0.001‡ |
| Hematologic CR achievement | 51/52 (98.1%) | 23/26 (88.5%) | 0.070§ |
| Relapse after 1st CR | 5/51 (9.80%) | 4/23 (17.4%) | 0.446§ |
| JL1 expression (%) | 50.69 ± 32.23 | 54.41 ± 34.95 | 0.642† |
| JL1 incidence | 40/52 (76.9%) | 22/26 (84.6%) | 0.557§ |
| RGA from PCR | 19/52 (36.5%) | 14/26 (53.8%) | 0.145§ |
| PCR results (N of patients) | FUS-ERG (2) | KMT2A-MLLT3 (3) | NA |
| KMT2A-AFF1 (2) | RUNX1-RUNX1T1 (6) | ||
| ETV6-RUNX1 (6) | PML-RARA (2) | ||
| BCR-ABL1 (3) | CBFB-MYH11 (3) | ||
| TCF3-PBX1 (6) | SET-NUP214 (1) | ||
| KMT2A-MLLT1 (2) | Normal (11) | ||
| Normal (31) | |||
| Karyotype results (N of patients) | add(7)(q22) (1) | inv(16)(p13.1q22) (3) | NA |
| add(9)(p21) (1) | complex (3) | ||
| t(9;22)(q34;q11.2) (3) | del(13q) (1) | ||
| complex (7) | del(9q) (1) | ||
| del(9p) (2) | t(9;11)(p22;q23) (3) | ||
| +10 (1) | t(15;17)(q24;q21) (2) | ||
| t(16;21)(p11.2;q22) (2) | t(8;21)(q22;q22) (6) | ||
| hyperdiploidy (10) | +8 (2) | ||
| t(4;11)(q21;q23) (2) | Normal (5) | ||
| t(11;19)(q23;p13.3) (2) | |||
| t(8;9)(q24.3;p13) (1) | |||
| t(2;16)(p11.2;p11.2) (1) | |||
| t(1;19)(q23;p13.3) (6) | |||
| Normal (13) |
*These variables did not show normal distribution in the Kolmogorov-Smirnov test; thus, the median values and ranges are presented. All other continuous variables are presented as mean±SD.
P values were obtained from the Student t-test†, Mann-Whitney U test‡ and chi-square/Fisher's exact test§; ∥The 52 patients with ALL included 48 patients with B-ALL and 4 patients with T-ALL.
Abbreviations: M, male; F, female; WBC, white blood cells; PLT, platelets; PB, peripheral blood; BM, bone marrow; Dx, diagnosis; CR, complete remission; RGA, recurrent genetic abnormalities included in the 2016 WHO classification; NA, not applicable; add, addition; t, translocation; inv, inversion; del, deletion.