Table 3.

Univariate and multivariate variance analysis for PD-L1 and PD-1 expression.

		PD-L1				PD-1
		Univariate		Multivariate		Univariate		Multivariate
Variables		Mean (SD)	p-value	F	p-value	Mean (SD)	p-value	F	p-value
Age	<60	6.20(1.55)	0.054			5.24(1.76)	0.164
	>=60	6.48(1.69)				5.45(1.55)
P16	Negative	6.55(1.54)	0.860			5.30(1.64)	0.0002	4.66	0.033
	Positive	6.45(1.66)				6.62(1.85)
Stage	I	7.17(1.68)	0.019	3.64	0.013	5.70(1.34)	0.407
	II	6.67(1.55)				5.42(1.83)
	III	6.34(1.82)				5.29(1.61)
	IV	6.21(1.54)				5.20(1.62)
EGFR	Unamplified	6.50(1.50)	0.680			5.74(1.70)	0.211
	Amplified	6.95(1.92)				4.85(1.87)
Grade	GX	6.69(1,23)	0.723			6.07(2.15)	0.001
	G1	6.53(1.67)				5.27(1.58)
	G2	6.28(1.58)				5.14(1.55)
	G3	6.40(1.75)				5.74(1.70)
	G4	6.41(1.30)				6.53(1.57)
Radiosensitivity	RR	4.44(1.30)	<0.0001	32.35	<0.0001	6.01(1.58)	0.0001	96.04	<0.0001
	RS	6.64(1.15)				6.85(1.62)

Abbreviations: Grade, neoplasm histologic grade; EGFR, Epidermal growth factor receptor amplification status; RR, radioresistant group; RS, radiosensitive group.