Table 4.
Associations between different mutations of KRAS and clinicpathological characteristics of patients.
| KRAS G12V mutation status | P - value | KRAS G12S mutation status | P- value | KRAS G12D mutation status | P- value | KRAS G12A mutation status | P- value | KRAS G13D mutation status | P- value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mutationn (%) | Wild typen (%) | Mutationn (%) | Wild typen (%) | Mutationn (%) | Wild typen (%) | Mutationn (%) | Wild typen (%) | Mutationn (%) | Wild typen (%) | ||||||
| Gender | |||||||||||||||
| Male | 1 (20.0) | 329 (68.5) | 0.038 | 3 (100 ) | 327 (67.8) | 0.555 | 3 (60.0) | 327 (68.1) | 1.000 | 0 | 330 (68.2) | 0.320 | 5 (83.3) | 325 (67.8) | 0.670 |
| Female | 4 (80.0) | 151 (31.5) | 0 | 155 (32.2) | 2 (40.0) | 153 (31.9) | 1 (100.0) | 154 (31.8) | 1 (16.7) | 154 (32.2) | |||||
| Age, years | |||||||||||||||
| <45 | 1 (20.0) | 58 (12.1) | 1.000 | 0 | 59 (12.2) | 0.272 | 0 | 59 (12.3) | 0.300 | 0 | 59 (12.2) | 1.000 | 1 (16.7) | 58 (12.1) | 1.000 |
| 45-49 | 0 | 42 (8.8) | 1 (33.3) | 41 ( 8.5) | 0 | 42 (8.8) | 0 | 42 (8.7) | 1 (16.7) | 41 (8.6) | |||||
| 50-70 | 3 (60.0) | 286 (59.6) | 1 (33.3) | 288 (59.8) | 5(100) | 284 (59.2) | 1 (100.0) | 288 (59.5) | 3 (50.0) | 286 (59.7) | |||||
| >70 | 1 (20.0) | 94 (19.5) | 1 (33.3) | 94 (19.5) | 0 | 95 (19.7) | 0 | 95 (19.6) | 1 (16.7) | 94 (19.6) | |||||
| TNM stage | |||||||||||||||
| I | 1 (20.0) | 67 (14.0) | 0.928 | 0 | 68 (14.1) | 0.385 | 0 | 68 (14.2) | 0.065 | 0 | 68 (14.0) | 1.000 | 0 | 68 (14.2) | 0.303 |
| II | 1 (20.0) | 100 (20.8) | 0 | 101 (21.0) | 3 (60.0) | 98 (20.4) | 0 | 101 (20.9) | 3 (50.0) | 98 (20.5) | |||||
| III | 1 (20.0) | 193 (40.2) | 1 (33.3) | 193 (40.0) | 0 | 194 (40.4) | 1 (100.0) | 193 (39.9) | 2 (33.3) | 192 (40.1) | |||||
| IV | 2 (40.0) | 120 (25.0) | 2 (66.7) | 120 (24.9) | 2 (40.0) | 120 (25.0) | 0 | 122 (25.2) | 1 (16.7) | 121 (25.3) | |||||
| Tumor location | |||||||||||||||
| Upper | 2 (40.0) | 145 (30.2) | 1.000 | 1 (33.3) | 146 (30.3) | 0.322 | 1 (20.0) | 146 (30.4) | 0.020 | 1 (100.0) | 146 (30.2) | 0.586 | 2 (33.3) | 145 (30.3) | 0.557 |
| Middle | 1 (20.0) | 90 (18.8) | 1 (33.3) | 90 (18.7) | 2 (40.0) | 89 (18.5) | 0 | 91 (18.8) | 2 (33.3) | 89 (18.6) | |||||
| Lower | 2 (40.0) | 199 (41.5) | 0 | 201 (41.7) | 0 | 201 (41.9) | 0 | 201 (41.5) | 1 (16.7) | 200 (41.8) | |||||
| Residual gastric or total gastric | 0 | 46 (9.5) | 1 (33.3) | 45 (9.3) | 2 (40.0) | 44 (9.2) | 0 | 46 (9.5) | 1 (16.7) | 42 (9.4) | |||||
| Lymph node status | |||||||||||||||
| pN0 | 3 (60.0) | 145 (30.2) | 0.562 | 0 | 148 (30.7) | 0.144 | 4 (80.0) | 144 (30.0) | 0.045 | 0 | 148 (30.6) | .122 | 3 (50.0) | 145 (30.3) | 0.664 |
| pN1 | 1 (20.0) | 136 (28.3) | 2 (66.7) | 135 (28.0) | 0 | 137 (28.5) | 0 | 137 (28.3) | 2 (33.3) | 135 (28.2) | |||||
| pN2 | 1 (20.0) | 140 (29.2) | 0 | 141 (29.3) | 0 | 141 (29.4) | 1 (100.0) | 141 (29.1) | 1 (16.7) | 140 (29.2) | |||||
| pN3a/b | 0 | 59 (12.3) | 1 (33.3) | 58 (2.0) | 1 (20.0) | 58 (12.1) | 0 | 58 (12.0) | 0 | 59 (12.3) | |||||