Table 1.
Selected demographic and clinical characteristics of epithelial ovarian cancer patients according to the average preoperative serum sodium levels measured in the 90 days prior to surgery
| Variables | Overall | Normal | Hyponatremia | P value † |
|---|---|---|---|---|
| No. of patients | 607 | 526 | 81 | |
| Age at diagnosis (years), Median (IQR) | 51 (47-59) | 51 (47-59) | 52 (47-59) | 0.44 |
| Follow-up time (years), Median (IQR) | 3.1 (2.18-4.21) | 3.02 (2.18-4.26) | 2.91 (2.16-3.80) | 0.27 |
| Serum potassium (mmol/L), Median (IQR) | 2.54 (1.21-3.88) | 4.06 (3.84-4.29) | 4.29 (3.86-4.59) | 0.15 |
| Serum albumin (g/L), Median (IQR) | 41 (36.7-44.1) | 41 (36.7-44.1) | 41 (37-43.4) | 0.83 |
| Serum creatinine (μmol/L), Median (IQR) | 54.1 (48.5-60.9) | 54 (48.5-61.1) | 55.3 (48.1-60.2) | 0.93 |
| Vital status (%) | 0.07 | |||
| Alive | 374 (61.6) | 332 (63.1) | 42 (51.8) | |
| Died | 233 (38.4) | 194 (36.9) | 39 (48.2) | |
| Recurrence status (%) | 0.09 | |||
| Yes | 345 (56.8) | 306 (58.2) | 39 (48.2) | |
| No | 262 (43.2) | 220 (41.8) | 42 (51.8) | |
| Comorbidity (%) | 0.78 | |||
| No | 336 (55.4) | 290 (55.1) | 46 (56.8) | |
| Yes | 271 (44.6) | 236 (44.9) | 35 (43.2) | |
| Performance status (%) | 0.57 | |||
| 0 | 4 (0.7) | 4 (0.8) | 0 | |
| 1 | 145 (23.9) | 125 (23.7) | 20 (24.7) | |
| 2 | 302 (49.8) | 265 (50.4) | 37 (45.7) | |
| ≥ 3 | 156 (25.6) | 132 (25.1) | 24 (29.6) | |
| FIGO stage (%) | 0.59 | |||
| I | 161 (26.5) | 144 (27.4) | 17 (21) | |
| II | 92 (15.2) | 78 (14.8) | 14 (17.3) | |
| III | 313 (51.6) | 270 (51.3) | 43 (53.1) | |
| IV | 41 (6.7) | 34 (6.5) | 7 (8.6) | |
| Histologic type (%) | 0.06 | |||
| Serous | 434 (71.5) | 369 (70.2) | 65 (80.3) | |
| Non-serous | 173 (28.5) | 157 (29.8) | 16 (19.7) | |
| Residual disease (%) | 0.81 | |||
| None detectable | 373 (61.4) | 321 (61) | 52 (64.2) | |
| ≤ 1 cm | 114 (18.8) | 99 (18.8) | 15 (18.5) | |
| > 1 cm | 120 (19.8) | 106 (20.2) | 14 (17.3) | |
| Ascites (%) | 0.26 | |||
| Yes | 257 (42.3) | 218 (41.4) | 39 (48.2) | |
| No | 350 (57.7) | 308 (58.6) | 42 (51.8) | |
| Grading (%) | 0.26 | |||
| Grade 1 | 31 (5.1) | 25 (4.8) | 6 (7.4) | |
| Grade 2 | 163 (26.9) | 137 (26.1) | 26 (32.1) | |
| Grade 3 | 413 (68) | 364 (69.1) | 49 (60.5) |
IQR, inter-quartile range.
†The Mann-Whitney U and chi-square tests were used for comparing continuous and category variables, respectively.