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Schematic of the contrast matching scheme used. Vesicles composed solely of d-DMPC (d54-DMPC) and h-DMPC are placed together in a H2O/D2O (55/45) mixture, contrast matched to an neutron scattering length density equal to fully mixed vesicles of d-DMPC and h-DMPC. Over time, because of lipid exchange and flip-flop, intensity loss can be monitored as vesicles mix and near the contrast match point.
