Figure 2.
Visualization of simulation setups for MA and DPA experiments. (a) Simulation of MA experiment. An underpressure ΔP is applied within a micropipette of radius Rp (top). The pressure is gradually increased (bottom) until the aspirated length ΔL = Rp. At this point, the pressure is registered as the critical pressure Pc. (b) Simulation of cell-cell adhesion. Two cells are brought in close proximity (top) and allowed to naturally adhere (bottom). (c) Simulation of DPA experiment, starting from a doublet of adhering cells. A pulling force Fp is applied on the cells (top) and gradually increased until rapid separation occurs (bottom). At this point, the pulling force is registered as the separation force Fs. To see this figure in color, go online.