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. 2019 Jan 24;116(5):930–937. doi: 10.1016/j.bpj.2019.01.015

Figure 4.

Figure 4

(a) Normalized DPA pull-off force Fs/πRˆw as a function of dextran-depletion-induced adhesion w between S180 cells, replotted from Fig. 2 in Chu et al. (7) (red diamonds), together with simulated DPA experiment at Ec = 15 kPa, tc = 0.3 μm, and γ = 0.4 n N/μm, as consistent with MA data (blue circles). Error bars indicate the experimental SD. Guide-lines with BWdG, JKR, and DMT limits are provided as indication. We have assumed R = 6 μm. (b) Parameter space of Ec, tc, and γ, with an isosurface obtained from simulations of MA on S180 cells, which delimits all parameter combinations for which the experimentally observed critical pressure Pc = 250 Pa (12) is attained. Colored dots represent new samples in this surface for which simulations of DPA were performed. The color scale indicates the value of F¯s=Fs/πRˆw obtained for an adhesion energy of w = 0.5 n N/μm. The overlaid rectangular lattice depicts the grid in which MA simulations were performed. To see this figure in color, go online.