Fig. 1.

Lysosomal enzymatic activities in different regions of the human postmortem brain. a Cluster analysis of average enzymatic activities across patients for GCase, β-Hex, and CathD in the different studied regions reveals that GCase activity was highest in the frontal cortex, while CathD and β-Hex activities were higher in the putamen compared to the other studied regions. b, c, and d Correlation matrices for lysosomal enzymatic activities and PMD for frontal cortex (b), putamen (c), and SN (d). High correlations were sometimes observed between activities of different lysosomal enzymes, but not with PMD. Values represent Spearman’s correlation coefficients. *p < 0.05; **p < 0.01; ***p < 0.001