Fig. 2.

Lysosomal enzyme activities in the brain of PD and DLB patients compared to controls. Group comparison of measured specific activities for β-Hex (a), GCase (b), and CathD (c) expressed in pmol/min/mg of proteins. Graphs show the average specific activity and standard deviation for non-demented controls (blue), PD patients (green), and DLB patients (blue). d. Overview of mean enzyme activities ± standard deviations. The p value indicates the between-group difference per brain region. GCase activity was significantly decreased in the SN of PD patients compared to controls, while lower CathD activity was found in the frontal cortex of DLB patients compared to controls *p < 0.05