Fig. 3.

mRNA expression levels for GBA, CTSD, and other ALP components. Correlation matrices showing association between mRNA expression levels of GBA and genes encoding CTSD, GCase’s protein interactors LIMP-2 (SCARB2) and saposin C (PSAP), and the lysosomal membrane-associated protein LAMP-1 in the frontal cortex (a) and SN (b). Normalized mRNA expression levels for GBA (c), CTSD (d), and SCARB2 (e) in PD (green) and DLB (red) patients as well as non-demented controls (blue). Expression levels are expressed as percentage of the average expression level of non-demented controls. f Schematic outline of the interplay between the measured gene products. LIMP-2 functions as a transporter molecule for GCase from the endoplasmatic reticulum, while the interaction of GCase with SapC is essential for its proper function [31]. LAMP-1 and LAMP-2a are lysosome-associated membrane proteins, while transcription factor EB (TFEB) is the master regulator of biogenesis and function of lysosomes, by activating transcription of autophagy-related genes (ATGs). *p < 0.05; **p < 0.01; ***p < 0.001