Table 1.
Cohort demographics. *p < 0.05 (Pearson chi-square test)
Controls (N = 15) | PD (N = 15) | DLB (N = 15) | p value | |
---|---|---|---|---|
Age of death (years ± SD) | 77 ± 6 | 77 ± 5 | 77 ± 5 | 0.67 |
Sex (M/F) | 4/11 | 11/4 | 10/5 | 0.02* |
Postmortem delay (hours ± SD) | 6.3 ± 1.7 | 6.0 ± 1.8 | 5.2 ± 1.2 | 0.47 |
Braak Lewy Body Score | 0–1 (14/1) | 4–6 (3/5/7) | 4–6 (3/3/9) | < 0.01* |
Braak score for Neurofibrillary Tangles | 0–2 (2/6/7) | 0–3 (2/9/2/2) | 0–3 (1/8/5/1) | 0.46 |
CERAD Amyloid Plaque Score | 0-B (4/7/4) | O-C (7/5/2/1) | O-C (3/3/8/1) | 0.21 |
Disease duration (years ± SD) | – | 15 ± 7 | 6 ± 3 | < 0.01* |
No. of donors with GBA risk factors | 2 | 3 | 4 | – |
No. of donors with pathogenic GBA variants | 0 | 3 | 0 | – |