FIGURE 1.

Metformin attenuates cell hypertrophy in response to metabolic stress. (A) Representative images of H9C2 cells exposed to vehicle (C) or 2 mM 2-deoxyglucose (2DG) for 24 h in the presence or absence of 5 mM metformin (M). (B) Quantification of cell area from (A). Data represents the mean ± SEM from at least three independent experiments. Scale bar is 100 μm. Statistical analysis was carried out by one-way ANOVA: ^∗∗∗P < 0.001 between indicated conditions.