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Metformin abolishes cell apoptosis in response to metabolic stress. (A) Representative images of TUNEL staining of cultured H9C2 cells exposed to 2 mM 2-deoxyglucose (2DG) in the presence or absence of 5 mM metformin (M). (B) Quantification of apoptosis from (A). Scale bar is 100 μm. Data represents the mean ± SEM from at least three independent experiments. Statistical analysis was carried out by one-way ANOVA: ∗∗∗P < 0.001 between indicated conditions.
