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. 2019 Feb 27;7:99. doi: 10.3389/fchem.2019.00099

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Copyright © 2019 Bonomo, Barbero, Naponiello, Giordano, Dini and Barolo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme 1 — Scheme of the synthesis of VG21-C12. Reagents and conditions: (i) 1-iodododecane, acetonitrile, microwave, 155°C, 60 min; (ii) squaric acid, toluene/n-butanol (1:1), MW, 160°C, 30 min; (iii) 5-formyl-2-thienylboronic acid, [PdCl₂(dppf)]·CH₂Cl₂, K₂CO₃, toluene/MeOH (1:1), microwave, 70°C, 20 min; (iv) cyanoacetic acid, piperidine, acetonitrile, microwave, 100°C, 60 min.