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. 2019 Mar 5;9:3574. doi: 10.1038/s41598-019-40285-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cross-species comparisons of PMN-MDSCs highlight common transcriptomic signatures across three mammalian taxa. (a) Similarity score (square) and p-value (circle) are graphed using the top 100–500 canine and human PMN-MDSC differentially expressed genes input into the ‘OrderedList’ R program. Dashed line indicates p = 0.05, and up to the top 500 genes are statistically similar in both species. (b,c) Venn diagram comparing upregulated genes in canine and human (b) and canine, human, and murine (c) PMN-MDSCs relative to C PMNs. Only those genes with a FC ≥ 2 and FDR ≤ 0.05 were included in this analysis. (d) Bar chart comparing the fold change of the five conserved genes across the three species.