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. 2019 Mar 5;9:3617. doi: 10.1038/s41598-019-40218-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of CHK1 inhibitors on CPX-351-induced apoptosis in additional AML cell lines. HL-60 (a), ML-2 (b), THP.1 (c) or MV-4-11 cells (d) were treated for 24 h with varying concentrations of CPX-351 in the absence of presence of MK-8776, rabusertib or prexasertib as indicated, stained with PI and subjected to flow microfluorimetry. Left panels show results from single experiment. Right panels show summary of 3–6 experiments. Results of single-agent MK-8776 in ML-2 cells are shown in Supplementary Figure S4a. Middle panel in c, plot showing combination index values for experiment shown in left panel. A combination index <1 indicates synergy⁴⁷. * and **p < 0.002 (n = 4) and p < 0.02 (n = 3) relative to samples treated with CPX-351 plus diluent.