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. 2019 Mar 5;9:3617. doi: 10.1038/s41598-019-40218-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of CPX-351 and MK-8776 on colony formation assays in human AML cell lines and primary AML specimens. (a,b) U937 (a) or HL-60 cells (b) were treated for 24 h with CPX-351 alone and in combination with 600 nM MK-8776, washed, plated in soft agar for 12 days and counted. (c–e) Marrow mononuclear cells from AML patients (Supplementary Table S1) were plated in cytokine-containing Methocult® methylcellulose containing the indicated concentration of CPX-351 in addition to diluent (0.1% DMSO) or 100 nM MK-8776. After a 14-day incubation, leukemic colonies were counted.