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. 2019 Feb 27;13:68. doi: 10.3389/fncel.2019.00068

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Copyright © 2019 Yang, Chen, Zhao, Luo, Xu, Du, Wang, Li, Yang, Hu, Zhang, Li, Xia, Chen, Ma, Tian and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of spatial learning and memory function in T2DM rat. Rats in the model group showed a significant increase of escape latency and a significant decrease of the number of platform cross times. The COX2 inhibitor could significantly blunt those changes caused by T2DM. Data are expressed as mean ± SD of nine individual rats in each group, and were analyzed statistically using one-way ANOVA, followed by post hoc Tukey’s test. ^∗P < 0.05 and ^∗∗P < 0.01 compared with normal group; ^#P < 0.05 and ^##P < 0.01 compared with model group, respectively.