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. 2019 Feb 27;13:68. doi: 10.3389/fncel.2019.00068

FIGURE 7.

FIGURE 7

Changes of p-AKT(S473), p-AMPK(T172), Aβ, Beclin1, LC3BII, and p62 expressions in rat cortex and hippocampus. (A) The changes of proteins in cortex. (B) The changes of proteins in hippocampus. Compared with normal group, the expressions of p-AKT(S473), Aβ, Beclin1, and p62 were significantly increased, while p-AMPK(T172) and LC3BII expression was significantly decreased in the model group. The COX2 inhibitor significantly increased the expression of p-AMPK(T172), Beclin1 and LC3BII, while significantly decreased the expression of p-AKT(S473), Aβ, and p62. The relative protein level was standardized to endogenous β-actin protein for each sample. Data are expressed as mean ± SD of four individual rats in each group, and were analyzed statistically using one-way ANOVA, followed by post hoc Tukey’s test. ∗P < 0.05 and ∗∗P < 0.01 compared with normal group; #P < 0.05 and ##P < 0.01 compared with model group, respectively.