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. 2019 Mar 5;9:3606. doi: 10.1038/s41598-019-40342-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TMEM10 is expressed by oligodendrocytes in remyelinating MS plaques –(a–f) Brain tissue samples containing an inflammatory demyelinating lesion consistent with MS were stained for CD68 and CD3 (markers of infiltrating immune cells), Neurofilament (axons), Olig2 (oligodendrocyte lineage cells), and TMEM10. NOGOA and MBP expression indicate ongoing remyelination in these plaques. (g) A subset of cells with oligodendroglial morphology expresses TMEM10. (h–k) Double staining for TMEM10 and Olig2 confirms that TMEM10 expressing cells are oligodendrocytes. Scale bars correspond to 200 µm in (a,b), 100 µm in (c), 50 µm in (d) through (h) and 25 µm.