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. 2019 Feb 27;10:330. doi: 10.3389/fimmu.2019.00330

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Copyright © 2019 Kirchner, Littringer, Altmeier, Tran, Schönherr, Lemberg, Pagni, Sanglard, Joller and LeibundGut-Landmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The host response to C. albicans strain 101 is delayed compared to strain SC5314. Epithelial sheet from C. albicans strain SC5314- and strain 101-infected WT mice were subjected to RNA-seq analysis. (A) Graph showing the total number of differentially expressed (DE) genes at the indicated time points compared to naïve controls. (B) Separate display of the up- and down-regulated genes at the indicated time points. (C) Volcano plots displaying the fold changes and the FDR of all genes detected in each condition separately. Genes with FDR < 0.05 and fold change < −2 or > 2 are marked in red.