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. 2019 Mar 5;10:1060. doi: 10.1038/s41467-019-08936-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Sex-specific effect sizes and cumulative variance explained by lead SNPs at the 27 genetic loci for glycine. a Sex-specific effect sizes of lead SNPs at the significant loci for glycine levels based on a meta-analysis of the Fenland, EPIC-Norfolk and INTERVAL studies, including 30,226 men and 31,957 women. b Cumulative variance in glycine levels explained (r²) by lead SNPs at all 27 loci in men (N = 5086) and women (N = 5706) of the EPIC-Norfolk study (sub-cohorts A and B)