Fig. 4.

Forest plot of the odds ratios ± 95% confidence intervals for coronary heart disease per standard deviation observationally or genetically predicted higher levels of glycine. Genetic estimates are based on 88,800 CHD cases and 485,266 controls. Sex-specific genetic analyses included 9,852 female and 21,994 male CHD cases and 202,124 female and 164,944 male controls. For the sex-specific analyses, sex-specific standard deviations for glycine were used, which were 0.321 and 0.195 (arbitrary units) for women and men in EPIC-Norfolk, respectively. Observational analyses are based on 11,147 participants (4989 men and 6158 women), of which 2053 (1223 men and 830 women) were incident CHD cases