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. 2019 Feb 27;10:304. doi: 10.3389/fimmu.2019.00304

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Copyright © 2019 Figliuolo da Paz, Jamwal, Gurney, Midura-Kiela, Harrison, Cox, Wilson, Ghishan and Kiela.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DAB2 is downregulated in human and murine dendritic cells after Toll-like receptor activation through MyD88 and TRIF pathways. (A) Bone-marrow derived dendritic cells (BMDC) differentiated from C57BL/6J mice, DC2.4 cells, and human monocytes-derived dendritic cells were incubated with 100 ng/mL LPS, and DAB2 expression was quantified using western blotting. (B) DAB2 expression in BMDCs treated with agonist for extracellular TLR or (C) agonist for intracellular TLR. (D,E) DAB2 expression after treatment with HKLM, HMW, or LPS in BMDC differentiated from WT, MyD88^−/−, and or TRIF^−/− C57BL/6 mice. Bar graphs represent mean values of three independent experiments combined (n = 3 mice, **p < 0.01, ****p < 0.001 treatment vs. Ctrl within the same genetic background).