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. 2019 Feb 27;10:304. doi: 10.3389/fimmu.2019.00304

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Copyright © 2019 Figliuolo da Paz, Jamwal, Gurney, Midura-Kiela, Harrison, Cox, Wilson, Ghishan and Kiela.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DAB2 expression modulates DC response to TLR activation. mRNA expression of (A) Tnf and Il6, (B) Il23a and Ifnβ1, (C) Il1β, and (D) Tlr4, Traf6, and Irf3 6 h after exposure of DC2.4^WT or DC2.4^Dab2−/− cells to 100 ng/mL LPS, evaluated by qRT-PCR with Tbp used as an internal control. (E) Expression of cell surface DC activation markers CD40, CD80, MHCII, and CD11b in DC2.4^WT vs. DC2.4^Dab2−/− cells treated with vehicle (Ctrl) or 100 ng/mL LPS for 24 h was evaluated by flow cytometry and expressed as mean fluorescence intensity (MFI). Data represent mean values of n = 3–6. (*p < 0.05, **p < 0.01, ***p < 0.05 and ****p < 0.001 Ctrl vs. LPS for DC2.4^WT or DC2.4^Dab2−/− cells. ^#p < 0.05 and ^###p < 0.005, ^####p < 0.001 when DC2.4^WT vs. DC2.4^Dab2−/− cells in the same treatment groups).