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. 2019 Mar 5;9:3470. doi: 10.1038/s41598-019-39143-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Severe symptoms of malaria retinopathy affecting large vessels. Examination of a representative infected mouse at 6DPI. (A) SLO native imaging with IR mode depicting the position of the respective OCT scan (D). (B) SLO native imaging in RF mode revealed large areas of retinal whitening (asterisks) that could be correlated to areas of non-perfusion (C, asterisks), vascular dilation in native imaging (A, arrow) and in ICG angiography (C, arrow), as well as with fluid accumulation seen in OCT imaging (D, arrowhead). (E) Histological sections detected sequestration of parasites in choroidal vessels. GFP expressing plasmodia (green), vascular CF8 staining (red). Scale bar in D = 200 µm; E = 40 µm.