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. 2019 Mar 5;9:3470. doi: 10.1038/s41598-019-39143-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Longitudinal analysis of malaria retinopathy during treatment with DHA. (A–F) SLO imaging: (A,D) in RF mode, (B,E) GFP detection in AF mode, (C,F) ICG angiography. ROIs (I–IV); (G) histological section. (H) OCT sections corresponding to ROIs in the SLO images. ROIs I, IV show infected areas, while ROIs II, III show unaffected regions with healthy fundus appearance in SLO and normal retinal layering as assessed by OCT. (A–C, H I and II) show the analysis at 10DPI (i.e. after 4 days of DHA treatment). (D–G, H III and IV) show the 18DPI time point (12 days of treatment). Scale bars in G = 20 µm; H = 200 µm.