Table 2.
Numbers of animals showing marked changes at different in vivo examinations.
| Method/Exam | 3DPI | 6DPI | 10DPI | 18DPI |
|---|---|---|---|---|
| Parasitaemia in blood stream (also: GFP-labelled parasites moving in blood stream as observed in SLO; cf. Suppl. Fig. 2A) |
11/11 100% |
11/11 100% |
1/6 17% |
0/4 0% |
| OCT: Localized retinal layer alterations (at least 5 alterations, in at least 3 OCT scans) |
11/11 100% |
11/11 100% |
6/6 100% |
4/4 100% |
| SLO: Immobile GFP-labelled parasites (at least 10 GFP-labelled spots in visible fundus) |
11/11 100% |
11/11 100% |
6/6 100% |
4/4 100% |
| Histology (ex vivo): GFP detection, GFAP immunoreactivity (cf. Figs 5 and 6) | — | 5/5 100% |
— | 4/4 100% |
Animals were investigated at four consecutive points in time after infection with malaria (days post-infection; DPI). Data is expressed as the number of animals positive for a certain marker vs. the total number of animals examined, or as percentage. After the 6DPI exam, five animals were sacrificed, while six animals received DHA anti-malarial treatment and were investigated for a further 12 days.